Vancomycin » PTA » AUC/MIC

Vancomycin » Probability of Target Attainment » AUC to MIC ratio

simulate_vancomycin_mc_pta_auc_mic_ratio(
  PATID,
  AGE,
  HEIGHT,
  WEIGHT,
  GENDER,
  CREATININE,
  MODEL,
  AUCPERMIC,
  CRCLCAP,
  REGIMENS
)

Arguments

PATID	Patient Identifier. User-provided free text (such as patient id, name or alias) to identify related simulations. Must be provided as string.
AGE	Age. Age of the patient in years. Must be provided as numeric (min. 18, max. 120 year).
HEIGHT	Height. Height of the patient. Must be provided as numeric (min. 100, max. 250 cm).
WEIGHT	Weight. Actual body weight of the patient. Must be provided as numeric (min. 20, max. 500 kg).
GENDER	Sex. Patient's sex for clinical decision-making. Must be provided as string ('Male' or 'Female').
CREATININE	Creatinine. Serum creatinine. Must be provided as numeric (min. 0.01, max. 15 mg/dL).
MODEL	Model for population of interest. Pharmacokinetic model to be used for specific patient type during simulations. Must be provided as string ('Goti et al. (2018) - Patients NOT undergoing hemodialysis', 'Goti et al. (2018) - Patients undergoing hemodialysis', 'Buelga et al. (2005) - Patients with hematological malignancies', 'Buelga et al. (2005) - AML patients, Model 1' or 'Buelga et al. (2005) - AML patients, Model 2').
AUCPERMIC	AUC to MIC ratio target. The PK/PD target can be provided as 24 hour area under the concentration-time curve to minimum inhibitory concentration ratio (AUC/MIC). Must be provided as numeric (min. 10, max. 2000 ).
CRCLCAP	Capping Creatinine Clearance. Whether to use capping for creatinine clearance. Must be provided as string ('No cap', '120 ml/min', '130 ml/min', '140 ml/min' or '150 ml/min').
REGIMENS	Dosing Regimens. List of dosing regimens to be used in simulating target attainment, from which the dosing regimen with the smallest absolute difference from the desired target will be automatically selected. Must be provided as list of 1-8 'REGIMEN' values. Use the regimen helper function to define the REGIMEN values.

Details

Drug: Vancomycin

Method: Monte Carlo simulation on the probabilities that a specific value of a pharmacodynamic index is achieved in case of different minimum inhibitory concentrations (MIC).

PK/PD target: 24 hour area under the concentration-time curve to minimum inhibitory concentration ratio.

References

• Goti et al. (2018): Hospitalized Patients With and Without Hemodialysis Have Markedly Different Vancomycin Pharmacokinetics: A Population Pharmacokinetic Model-Based Analysis. In. Therapeutic Drug Monitoring. https://pubmed.ncbi.nlm.nih.gov/29470227/

• Buelga, Dolores Santos et al. (2005): Population Pharmacokinetic Analysis of Vancomycin in Patients with Hematological Malignancies. In. Antimicrobial Agents and Chemotherapy. https://aac.asm.org/content/49/12/4934

Examples

if (FALSE) {
simulate_vancomycin_mc_pta_auc_mic_ratio(PATID = "Anonymous", 
    AGE = 35, HEIGHT = 155, 
    WEIGHT = 55, GENDER = "Female", 
    CREATININE = 1.2, 
    MODEL = "Goti et al. (2018) - Patients undergoing hemodialysis", 
    AUCPERMIC = 400, 
    CRCLCAP = "No cap", 
    REGIMENS = list(list(
        DOSE = 2000, 
        INTERVAL = 16, 
        TINF = 2, set = "REGIMEN")))
}