Tobramycin » PTA » Cmin/MIC

Source: R/simulate_tobramycin_mc_pta_cmin_mic_ratio.R

Tobramycin » Probability of Target Attainment » Total minimum concentration to MIC ratio

simulate_tobramycin_mc_pta_cmin_mic_ratio(
  PATID,
  AGE,
  HEIGHT,
  WEIGHT,
  GENDER,
  MODEL,
  CREATININE,
  CMINPERMIC,
  REGIMENS
)

Arguments

PATID

Patient Identifier. User-provided free text (such as patient id, name or alias) to identify related simulations. Must be provided as string.
AGE

Age. Age of the patient in years. Must be provided as numeric (min. 18, max. 120 year).
HEIGHT

Height. Height of the patient. Must be provided as numeric (min. 100, max. 250 cm).
WEIGHT

Weight. Actual body weight of the patient. Must be provided as numeric (min. 20, max. 500 kg).
GENDER

Sex. Patient's sex for clinical decision-making. Must be provided as string ('Male' or 'Female').
MODEL

Model for population of interest. Pharmacokinetic model to be used for specific patient type during simulations. Must be provided as string ('Pai et al. (2011) - General ward').
CREATININE

Creatinine. Serum creatinine. Must be provided as numeric (min. 0.01, max. 15 mg/dL).
CMINPERMIC

Minimum concentration to MIC ratio target. The PK/PD target can be provided as minimum concentration to minimum inhibitory concentration ratio (Cmin/MIC). Must be provided as numeric (min. 0.1, max. 50 ).
REGIMENS

Dosing Regimens. List of dosing regimens to be used in simulating target attainment, from which the dosing regimen with the smallest absolute difference from the desired target will be automatically selected. Must be provided as list of 1-8 'REGIMEN' values. Use the regimen helper function to define the REGIMEN values.

Details

Drug: Tobramycin

Method: Monte Carlo simulation on the probabilities that a specific value of a pharmacodynamic index is achieved in case of different minimum inhibitory concentrations (MIC).

PK/PD target: Minimum concentration (mg/L) to minimum inhibitory concentration ratio (mg/L).

References

  • Pai et al. (2011): Simplified Estimation of Aminoglycoside Pharmacokinetics in Underweight and Obese Adult Patients. In. Antimicrobial Agents and Chemotherapy. https://aac.asm.org/content/55/9/4006

Examples

if (FALSE) {
simulate_tobramycin_mc_pta_cmin_mic_ratio(PATID = "Anonymous", 
    AGE = 35, HEIGHT = 155, 
    WEIGHT = 55, GENDER = "Female", 
    MODEL = "Pai et al. (2011) - General ward", 
    CREATININE = 1.0638498, 
    CMINPERMIC = 2, REGIMENS = list(
        list(DOSE = 200, 
            INTERVAL = 6, 
            TINF = 0.5, 
            set = "REGIMEN")))
}