Tobramycin » Empiric » AUC/MIC

Tobramycin » Empiric therapy » AUC to MIC ratio

simulate_tobramycin_mc_emp_auc_mic_ratio(
  PATID,
  AGE,
  HEIGHT,
  WEIGHT,
  GENDER,
  MODEL,
  CREATININE,
  MIC,
  AUCPERMIC,
  LOADINGDOSE,
  REGIMENS
)

Arguments

PATID	Patient Identifier. User-provided free text (such as patient id, name or alias) to identify related simulations. Must be provided as string.
AGE	Age. Age of the patient in years. Must be provided as numeric (min. 18, max. 120 year).
HEIGHT	Height. Height of the patient. Must be provided as numeric (min. 100, max. 250 cm).
WEIGHT	Weight. Actual body weight of the patient. Must be provided as numeric (min. 20, max. 500 kg).
GENDER	Sex. Patient's sex for clinical decision-making. Must be provided as string ('Male' or 'Female').
MODEL	Model for population of interest. Pharmacokinetic model to be used for specific patient type during simulations. Must be provided as string ('Pai et al. (2011) - General ward').
CREATININE	Creatinine. Serum creatinine. Must be provided as numeric (min. 0.01, max. 15 mg/dL).
MIC	MIC. Minimum Inhibitory Concentration (MIC). Must be provided as numeric (min. 0.01, max. 1024 mg/L).
AUCPERMIC	AUC to MIC ratio target. The PK/PD target can be provided as 24 hour area under the concentration-time curve to minimum inhibitory concentration ratio (AUC/MIC). For selecting an appropriate target please refer to the dosing guideline of your institution, e.g. <a href="http://med.stanford.edu/bugsanddrugs/guidebook/_jcr_content/main/panel_builder_584648957/panel_0/download_1194988017/file.res/Aminoglycoside%20Dosing%20Guide%202019-05-20.pdf" target="_new">Stanford Health Care Aminoglycoside Dosing Guide</a>. Must be provided as numeric (min. 10, max. 2000 ).
LOADINGDOSE	Loading dose. Loading dose is desired or not. Must be provided as string ('No' or 'Yes').
REGIMENS	Dosing Regimens. List of dosing regimens to be used in simulating target attainment, from which the dosing regimen with the smallest absolute difference from the desired target will be automatically selected. Must be provided as list of 1-20 'REGIMEN' values. Use the regimen helper function to define the REGIMEN values.

Details

Drug: Tobramycin

Method: Simulate concentrations for multiple dosing regimens and select the optimal one, with regard to the target pharmacodynamic index.

PK/PD target: 24 hour area under the concentration-time curve to minimum inhibitory concentration ratio.

References

• Pai et al. (2011): Simplified Estimation of Aminoglycoside Pharmacokinetics in Underweight and Obese Adult Patients. In. Antimicrobial Agents and Chemotherapy. https://aac.asm.org/content/55/9/4006

Examples

if (FALSE) {
simulate_tobramycin_mc_emp_auc_mic_ratio(PATID = "Anonymous", 
    AGE = 65, HEIGHT = 175, 
    WEIGHT = 75, GENDER = "Male", 
    MODEL = "Pai et al. (2011) - General ward", 
    CREATININE = 0.876056338, 
    MIC = 1, AUCPERMIC = 150, 
    LOADINGDOSE = "No", 
    REGIMENS = list(list(
        set = "REGIMEN", 
        DOSE = 100, INTERVAL = 8, 
        TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 100, 
            INTERVAL = 12, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 125, 
            INTERVAL = 8, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 125, 
            INTERVAL = 12, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 150, 
            INTERVAL = 8, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 150, 
            INTERVAL = 12, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 175, 
            INTERVAL = 8, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 175, 
            INTERVAL = 12, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 200, 
            INTERVAL = 8, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 200, 
            INTERVAL = 12, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 400, 
            INTERVAL = 24, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 400, 
            INTERVAL = 36, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 500, 
            INTERVAL = 24, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 500, 
            INTERVAL = 36, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 600, 
            INTERVAL = 24, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 600, 
            INTERVAL = 36, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 700, 
            INTERVAL = 24, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 700, 
            INTERVAL = 36, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 800, 
            INTERVAL = 24, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 800, 
            INTERVAL = 36, 
            TINF = 0.5)))
}