Meropenem » Bayesian » % fT > MIC

Meropenem » Bayesian adaptive dosing » Percent time of free concentration above MIC

simulate_meropenem_bayesian_ftime_above_mic(
  PATID,
  AGE,
  HEIGHT,
  WEIGHT,
  GENDER,
  MODEL,
  EDEMA,
  MIC,
  PCTABOVEMIC,
  CRCLCAP,
  HISTORY,
  REGIMENS
)

Arguments

PATID	Patient Identifier. User-provided free text (such as patient id, name or alias) to identify related simulations. Must be provided as string.
AGE	Age. Age of the patient in years. Must be provided as numeric (min. 18, max. 120 year).
HEIGHT	Height. Height of the patient. Must be provided as numeric (min. 100, max. 250 cm).
WEIGHT	Weight. Actual body weight of the patient. Must be provided as numeric (min. 20, max. 500 kg).
GENDER	Sex. Patient's sex for clinical decision-making. Must be provided as string ('Male' or 'Female').
MODEL	Model for population of interest. Pharmacokinetic model to be used for specific patient type during simulations. Must be provided as string ('Crandon et al. (2011) - ICU', 'Li, C. et. al. (2006) - General ward' or 'Doh, K. et al. (2010) - Burn patients').
EDEMA	Edema. Presence of edema in case of Burn Patients. Must be provided as string ('No' or 'Yes').
MIC	MIC. Minimum Inhibitory Concentration (MIC). Must be provided as numeric (min. 0.01, max. 1024 mg/L).
PCTABOVEMIC	Percent of time target that the drug concentration is above MIC. The PK/PD target can be provided as the percent of time that the drug concentration is above the minimum inhibitory concentration (% T > MIC). Must be provided as numeric (min. 5, max. 100 %).
CRCLCAP	Capping Creatinine Clearance. Whether to use capping for creatinine clearance. Must be provided as string ('No cap', '120 ml/min', '130 ml/min', '140 ml/min' or '150 ml/min').
HISTORY	Historical Records. Must be provided as list of 3-48 'HISTCREATININE', 'HISTDOSE' or 'HISTCONCENTRATION' values.
REGIMENS	Dosing Regimens. List of dosing regimens to be used in simulating target attainment, from which the dosing regimen with the smallest absolute difference from the desired target will be automatically selected. Must be provided as list of 1-20 'REGIMEN' values. Use the regimen helper function to define the REGIMEN values.

Details

Drug: Meropenem

Method: Estimate the pharmacokinetic parameters of the patient from past concentrations with Bayesian inverse modeling, then use that information to predict the steady state concentrations for multiple dosing regimens and select the optimal one, with regard to the target pharmacodynamic index.

PK/PD target: The percent of time that the free concentration is above the minimum inhibitory concentration.

References

• Jared L Crandon et al. (2011): Optimization of meropenem dosage in the critically ill population based on renal function. In. Intensive Care Medicine. https://pubmed.ncbi.nlm.nih.gov/21136037

• Li, C. et. al (2006): Population Pharmacokinetic Analysis and Dosing Regimen Optimization of Meropenem in Adult Patients. In. The Journal of Clinical Pharmacology. https://accp1.onlinelibrary.wiley.com/doi/10.1177/0091270006291035

• Doh, K. et al. (2010): Population pharmacokinetics of meropenem in burn patients. In. Journal of Antimicrobial Chemotherapy. https://academic.oup.com/jac/article/65/11/2428/762112

Examples

if (FALSE) {
simulate_meropenem_bayesian_ftime_above_mic(PATID = "Anonymous", 
    AGE = 65, HEIGHT = 175, 
    WEIGHT = 75, GENDER = "Male", 
    MODEL = "Crandon et al. (2011) - ICU", 
    EDEMA = "No", MIC = 1, 
    PCTABOVEMIC = 40, 
    CRCLCAP = "No cap", 
    HISTORY = list(list(
        DATETIME = structure(1601870400, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
        DOSE = 1000, 
        TINF = 2, set = "HISTDOSE"), 
        list(DATETIME = structure(1601899200, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            DOSE = 1000, 
            TINF = 1, 
            set = "HISTDOSE"), 
        list(DATETIME = structure(1601942400, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            DOSE = 750, 
            TINF = 1, 
            set = "HISTDOSE"), 
        list(DATETIME = structure(1601866800, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            CREATININE = 0.9, 
            set = "HISTCREATININE"), 
        list(DATETIME = structure(1601906400, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            CREATININE = 0.7, 
            set = "HISTCREATININE"), 
        list(DATETIME = structure(1601886600, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            CONCENTRATION = 12, 
            set = "HISTCONCENTRATION"), 
        list(DATETIME = structure(1601890200, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            CONCENTRATION = 8, 
            set = "HISTCONCENTRATION"), 
        list(DATETIME = structure(1601906400, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            CONCENTRATION = 20, 
            set = "HISTCONCENTRATION")), 
    REGIMENS = list(list(
        set = "REGIMEN", 
        DOSE = 500, INTERVAL = 6, 
        TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 500, 
            INTERVAL = 8, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 500, 
            INTERVAL = 12, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 500, 
            INTERVAL = 24, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 1000, 
            INTERVAL = 6, 
            TINF = 1), 
        list(set = "REGIMEN", 
            DOSE = 1000, 
            INTERVAL = 8, 
            TINF = 1), 
        list(set = "REGIMEN", 
            DOSE = 1000, 
            INTERVAL = 12, 
            TINF = 1), 
        list(set = "REGIMEN", 
            DOSE = 1000, 
            INTERVAL = 24, 
            TINF = 1), 
        list(set = "REGIMEN", 
            DOSE = 2000, 
            INTERVAL = 8, 
            TINF = 2), 
        list(set = "REGIMEN", 
            DOSE = 2000, 
            INTERVAL = 12, 
            TINF = 2), 
        list(set = "REGIMEN", 
            DOSE = 2000, 
            INTERVAL = 24, 
            TINF = 2)))
}