Meropenem » Bayesian adaptive dosing » Free minimum concentration to MIC ratio

simulate_meropenem_bayesian_fcmin_mic_ratio(
  PATID,
  AGE,
  HEIGHT,
  WEIGHT,
  GENDER,
  MODEL,
  EDEMA,
  MIC,
  CMINPERMIC,
  CRCLCAP,
  HISTORY,
  REGIMENS
)

Arguments

PATID

Patient Identifier. User-provided free text (such as patient id, name or alias) to identify related simulations. Must be provided as string.

AGE

Age. Age of the patient in years. Must be provided as numeric (min. 18, max. 120 year).

HEIGHT

Height. Height of the patient. Must be provided as numeric (min. 100, max. 250 cm).

WEIGHT

Weight. Actual body weight of the patient. Must be provided as numeric (min. 20, max. 500 kg).

GENDER

Sex. Patient's sex for clinical decision-making. Must be provided as string ('Male' or 'Female').

MODEL

Model for population of interest. Pharmacokinetic model to be used for specific patient type during simulations. Must be provided as string ('Crandon et al. (2011) - ICU', 'Li, C. et. al. (2006) - General ward' or 'Doh, K. et al. (2010) - Burn patients').

EDEMA

Edema. Presence of edema in case of Burn Patients. Must be provided as string ('No' or 'Yes').

MIC

MIC. Minimum Inhibitory Concentration (MIC). Must be provided as numeric (min. 0.01, max. 1024 mg/L).

CMINPERMIC

Minimum concentration to MIC ratio target. The PK/PD target can be provided as minimum concentration to minimum inhibitory concentration ratio (Cmin/MIC). Must be provided as numeric (min. 0.1, max. 50 ).

CRCLCAP

Capping Creatinine Clearance. Whether to use capping for creatinine clearance. Must be provided as string ('No cap', '120 ml/min', '130 ml/min', '140 ml/min' or '150 ml/min').

HISTORY

Historical Records. Must be provided as list of 3-48 'HISTCREATININE', 'HISTDOSE' or 'HISTCONCENTRATION' values.

REGIMENS

Dosing Regimens. List of dosing regimens to be used in simulating target attainment, from which the dosing regimen with the smallest absolute difference from the desired target will be automatically selected. Must be provided as list of 1-20 'REGIMEN' values. Use the regimen helper function to define the REGIMEN values.

Details

Drug: Meropenem

Method: Estimate the pharmacokinetic parameters of the patient from past concentrations with Bayesian inverse modeling, then use that information to predict the steady state concentrations for multiple dosing regimens and select the optimal one, with regard to the target pharmacodynamic index.

PK/PD target: Free minimum concentration (mg/L) to minimum inhibitory concentration ratio (mg/L).

References

  • Jared L Crandon et al. (2011): Optimization of meropenem dosage in the critically ill population based on renal function. In. Intensive Care Medicine. https://pubmed.ncbi.nlm.nih.gov/21136037

  • Li, C. et. al (2006): Population Pharmacokinetic Analysis and Dosing Regimen Optimization of Meropenem in Adult Patients. In. The Journal of Clinical Pharmacology. https://accp1.onlinelibrary.wiley.com/doi/10.1177/0091270006291035

  • Doh, K. et al. (2010): Population pharmacokinetics of meropenem in burn patients. In. Journal of Antimicrobial Chemotherapy. https://academic.oup.com/jac/article/65/11/2428/762112

Examples

if (FALSE) {
simulate_meropenem_bayesian_fcmin_mic_ratio(PATID = "Anonymous", 
    AGE = 65, HEIGHT = 175, 
    WEIGHT = 75, GENDER = "Male", 
    MODEL = "Crandon et al. (2011) - ICU", 
    EDEMA = "No", MIC = 1, 
    CMINPERMIC = 4, CRCLCAP = "No cap", 
    HISTORY = list(list(
        DATETIME = structure(1601870400, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
        DOSE = 1000, 
        TINF = 2, set = "HISTDOSE"), 
        list(DATETIME = structure(1601899200, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            DOSE = 1000, 
            TINF = 1, 
            set = "HISTDOSE"), 
        list(DATETIME = structure(1601942400, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            DOSE = 750, 
            TINF = 1, 
            set = "HISTDOSE"), 
        list(DATETIME = structure(1601866800, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            CREATININE = 0.9, 
            set = "HISTCREATININE"), 
        list(DATETIME = structure(1601906400, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            CREATININE = 0.7, 
            set = "HISTCREATININE"), 
        list(DATETIME = structure(1601886600, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            CONCENTRATION = 12, 
            set = "HISTCONCENTRATION"), 
        list(DATETIME = structure(1601890200, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            CONCENTRATION = 8, 
            set = "HISTCONCENTRATION"), 
        list(DATETIME = structure(1601906400, class = c("POSIXct", 
        "POSIXt"), tzone = ""), 
            CONCENTRATION = 20, 
            set = "HISTCONCENTRATION")), 
    REGIMENS = list(list(
        set = "REGIMEN", 
        DOSE = 500, INTERVAL = 6, 
        TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 500, 
            INTERVAL = 8, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 500, 
            INTERVAL = 12, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 500, 
            INTERVAL = 24, 
            TINF = 0.5), 
        list(set = "REGIMEN", 
            DOSE = 1000, 
            INTERVAL = 6, 
            TINF = 1), 
        list(set = "REGIMEN", 
            DOSE = 1000, 
            INTERVAL = 8, 
            TINF = 1), 
        list(set = "REGIMEN", 
            DOSE = 1000, 
            INTERVAL = 12, 
            TINF = 1), 
        list(set = "REGIMEN", 
            DOSE = 1000, 
            INTERVAL = 24, 
            TINF = 1), 
        list(set = "REGIMEN", 
            DOSE = 2000, 
            INTERVAL = 8, 
            TINF = 2), 
        list(set = "REGIMEN", 
            DOSE = 2000, 
            INTERVAL = 12, 
            TINF = 2), 
        list(set = "REGIMEN", 
            DOSE = 2000, 
            INTERVAL = 24, 
            TINF = 2)))
}