Cefepime » PTA » fCmin/MIC

Source: R/simulate_cefepime_mc_pta_fcmin_mic_ratio.R

Cefepime » Probability of Target Attainment » Free minimum concentration to MIC ratio

simulate_cefepime_mc_pta_fcmin_mic_ratio(
  PATID,
  AGE,
  HEIGHT,
  WEIGHT,
  GENDER,
  CREATININE,
  MODEL,
  CMINPERMIC,
  CRCLCAP,
  REGIMENS
)

Arguments

PATID

Patient Identifier. User-provided free text (such as patient id, name or alias) to identify related simulations. Must be provided as string.
AGE

Age. Age of the patient in years. Must be provided as numeric (min. 18, max. 120 year).
HEIGHT

Height. Height of the patient. Must be provided as numeric (min. 100, max. 250 cm).
WEIGHT

Weight. Actual body weight of the patient. Must be provided as numeric (min. 20, max. 500 kg).
GENDER

Sex. Patient's sex for clinical decision-making. Must be provided as string ('Male' or 'Female').
CREATININE

Creatinine. Serum creatinine. Must be provided as numeric (min. 0.01, max. 15 mg/dL).
MODEL

Model for population of interest. Pharmacokinetic model to be used for specific patient type during simulations. Must be provided as string ('Nicasio et al. (2009) - ICU' or 'Tam et al. (2003) - General ward').
CMINPERMIC

Minimum concentration to MIC ratio target. The PK/PD target can be provided as minimum concentration to minimum inhibitory concentration ratio (Cmin/MIC). Must be provided as numeric (min. 0.1, max. 50 ).
CRCLCAP

Capping Creatinine Clearance. Whether to use capping for creatinine clearance. Must be provided as string ('No cap', '120 ml/min', '130 ml/min', '140 ml/min' or '150 ml/min').
REGIMENS

Dosing Regimens. List of dosing regimens to be used in simulating target attainment, from which the dosing regimen with the smallest absolute difference from the desired target will be automatically selected. Must be provided as list of 1-8 'REGIMEN' values. Use the regimen helper function to define the REGIMEN values.

Details

Drug: Cefepime

Method: Monte Carlo simulation on the probabilities that a specific value of a pharmacodynamic index is achieved in case of different minimum inhibitory concentrations (MIC).

PK/PD target: Free minimum concentration (mg/L) to minimum inhibitory concentration ratio (mg/L).

References

  • Nicasio et al. (2009): Population Pharmacokinetics of High-Dose, Prolonged-Infusion Cefepime in Adult Critically Ill Patients with Ventilator-Associated Pneumonia. In. Antimicrobial Agents and Chemotherapy. https://pubmed.ncbi.nlm.nih.gov/19188394/

  • Tam et al. (2003): Pharmacokinetics and Pharmacodynamics of Cefepime in Patients with Various Degrees of Renal Function. In. Antimicrobial Agents and Chemotherapy. https://pubmed.ncbi.nlm.nih.gov/12760858/

Examples

if (FALSE) {
simulate_cefepime_mc_pta_fcmin_mic_ratio(PATID = "Anonymous", 
    AGE = 65, HEIGHT = 175, 
    WEIGHT = 75, GENDER = "Male", 
    CREATININE = 0.8760563, 
    MODEL = "Nicasio et al. (2009) - ICU", 
    CMINPERMIC = 4, CRCLCAP = "No cap", 
    REGIMENS = list(list(
        DOSE = 1000, 
        INTERVAL = 8, 
        TINF = 0.5, set = "REGIMEN")))
}