Cefepime » Empiric » fCmin

Cefepime » Empiric therapy » Free minimum concentration

simulate_cefepime_mc_emp_fcmin(
  PATID,
  AGE,
  HEIGHT,
  WEIGHT,
  GENDER,
  CREATININE,
  MODEL,
  MIC,
  CMIN,
  LOADINGDOSE,
  CRCLCAP,
  REGIMENS
)

Arguments

PATID	Patient Identifier. User-provided free text (such as patient id, name or alias) to identify related simulations. Must be provided as string.
AGE	Age. Age of the patient in years. Must be provided as numeric (min. 18, max. 120 year).
HEIGHT	Height. Height of the patient. Must be provided as numeric (min. 100, max. 250 cm).
WEIGHT	Weight. Actual body weight of the patient. Must be provided as numeric (min. 20, max. 500 kg).
GENDER	Sex. Patient's sex for clinical decision-making. Must be provided as string ('Male' or 'Female').
CREATININE	Creatinine. Serum creatinine. Must be provided as numeric (min. 0.01, max. 15 mg/dL).
MODEL	Model for population of interest. Pharmacokinetic model to be used for specific patient type during simulations. Must be provided as string ('Nicasio et al. (2009) - ICU' or 'Tam et al. (2003) - General ward').
MIC	MIC. Minimum Inhibitory Concentration (MIC). Must be provided as numeric (min. 0.01, max. 1024 mg/L).
CMIN	Minimum concentration target. The PK/PD target can be provided as minimum blood plasma concentration (Cmin). Must be provided as numeric (min. 0.1, max. 200 mg/L).
LOADINGDOSE	Loading dose. Loading dose is desired or not. Must be provided as string ('No' or 'Yes').
CRCLCAP	Capping Creatinine Clearance. Whether to use capping for creatinine clearance. Must be provided as string ('No cap', '120 ml/min', '130 ml/min', '140 ml/min' or '150 ml/min').
REGIMENS	Dosing Regimens. List of dosing regimens to be used in simulating target attainment, from which the dosing regimen with the smallest absolute difference from the desired target will be automatically selected. Must be provided as list of 1-20 'REGIMEN' values. Use the regimen helper function to define the REGIMEN values.

Details

Drug: Cefepime

Method: Simulate concentrations for multiple dosing regimens and select the optimal one, with regard to the target pharmacodynamic index.

PK/PD target: Free minimum blood plasma concentration (mg/L).

References

• Nicasio et al. (2009): Population Pharmacokinetics of High-Dose, Prolonged-Infusion Cefepime in Adult Critically Ill Patients with Ventilator-Associated Pneumonia. In. Antimicrobial Agents and Chemotherapy. https://pubmed.ncbi.nlm.nih.gov/19188394/

• Tam et al. (2003): Pharmacokinetics and Pharmacodynamics of Cefepime in Patients with Various Degrees of Renal Function. In. Antimicrobial Agents and Chemotherapy. https://pubmed.ncbi.nlm.nih.gov/12760858/

Examples

if (FALSE) {
simulate_cefepime_mc_emp_fcmin(PATID = "Anonymous", 
    AGE = 65, HEIGHT = 175, 
    WEIGHT = 75, GENDER = "Male", 
    CREATININE = 1, MODEL = "Nicasio et al. (2009) - ICU", 
    MIC = 1, CMIN = 17.5, 
    LOADINGDOSE = "No", 
    CRCLCAP = "No cap", 
    REGIMENS = list(list(
        DOSE = 750, INTERVAL = 8, 
        TINF = 1, set = "REGIMEN"), 
        list(DOSE = 750, 
            INTERVAL = 12, 
            TINF = 1, 
            set = "REGIMEN"), 
        list(DOSE = 750, 
            INTERVAL = 24, 
            TINF = 1, 
            set = "REGIMEN"), 
        list(DOSE = 1000, 
            INTERVAL = 8, 
            TINF = 1, 
            set = "REGIMEN"), 
        list(DOSE = 1000, 
            INTERVAL = 12, 
            TINF = 1, 
            set = "REGIMEN"), 
        list(DOSE = 1000, 
            INTERVAL = 24, 
            TINF = 1, 
            set = "REGIMEN"), 
        list(DOSE = 1250, 
            INTERVAL = 8, 
            TINF = 1.25, 
            set = "REGIMEN"), 
        list(DOSE = 1250, 
            INTERVAL = 12, 
            TINF = 1.25, 
            set = "REGIMEN"), 
        list(DOSE = 1250, 
            INTERVAL = 24, 
            TINF = 1.25, 
            set = "REGIMEN"), 
        list(DOSE = 1500, 
            INTERVAL = 8, 
            TINF = 1.5, 
            set = "REGIMEN"), 
        list(DOSE = 1500, 
            INTERVAL = 12, 
            TINF = 1.5, 
            set = "REGIMEN"), 
        list(DOSE = 1500, 
            INTERVAL = 24, 
            TINF = 1.5, 
            set = "REGIMEN"), 
        list(DOSE = 1750, 
            INTERVAL = 8, 
            TINF = 1.75, 
            set = "REGIMEN"), 
        list(DOSE = 1750, 
            INTERVAL = 12, 
            TINF = 1.75, 
            set = "REGIMEN"), 
        list(DOSE = 1750, 
            INTERVAL = 24, 
            TINF = 1.75, 
            set = "REGIMEN")))
}